SELEGILINE

SELEGILINE

14611-51-9

Synoyms:SELEGILINE BASE;dl-Depreny;N-(Methyl-d3),a-methyl-N-2-propyn-1-yl-benzeneethanamine;N-(Methyl-d3),a-methyl-N-2-propynyl Phenethylamine;SELEGILINEHYDROCHLORDE;(R)-(-)-Deprenyl;Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (aR)- (9CI);Benzeneethanamine, N,a-dimethyl-N-2-propynyl-, (R)-
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Antidyskinetic; antiparkinsonian (in combination with levodopa/carbidopa).Another drug used in the treatment of Parkinson’s disease is selegiline (also known as deprenyl, or Eldepryl). It is an irreversible inhibitor of MAO-B, an important enzyme in the metabolism of dopamine (Fig. 33.2). Blockade of dopamine metabolism makes more dopamine available for stimulation of its receptors. Selegiline, as monotherapy, may be effective in the newly diagnosed patient with parkinsonism because its

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